Spatial statistics of submicron size clusters of activating and inhibitory Natural Killer cell receptors in the resting state regulate early time signal discrimination.

ABSTRACT: Natural Killer (NK) cells are lymphocytes of the innate immunity and sense healthy or diseased target cells with activating and inhibitory NK cell receptor (NKR) molecules expressed on the cell surface. The protection provided by NK cells against viral infections and tumors critically depends on their ability to distinguish healthy cells from diseased target cells that express 100- fold more activating ligands. NK cell signaling and activation depend on integrating opposing signals initiated by activating and inhibitory NKRs interacting with the cognate ligands expressed on target cells. A wide range of imaging experiments have demonstrated aggregation of both activating and inhibitory NKRs in the plasma membrane on submicron scales in resting NK cells. How do these submicron size NKR clus

SUBMITTER: Ahmad S 

PROVIDER: S-EPMC11974869 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature