PIEZO1 Drives Trophoblast Fusion and Placental Development.

ABSTRACT: PIEZO1, a mechanosensor^1,2 in endothelial cells, plays a critical role in fetal vascular development during embryogenesis^3,4. However, its expression and function in placental trophoblasts remain unexplored. Here, we demonstrate that PIEZO1 is expressed in placental villus trophoblasts, where it is essential for trophoblast fusion and placental development. Mice with trophoblast-specific PIEZO1 knockout exhibit embryonic lethality without obvious vascular defects. Instead, PIEZO1 deficiency disrupts the formation of the syncytiotrophoblast layer in the placenta. Mechanistically, PIEZO1-mediated calcium influx activates TMEM16F lipid scramblase, facilitating the externalization of phosphatidylserine, a key "fuse-me" signal for trophoblast fusion^5,6. These fi

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC11974931 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature