SYS-1/beta-catenin inheritance and regulation by Wnt signaling during asymmetric cell division.

ABSTRACT: Asymmetric cell division (ACD) allows daughter cells of a polarized mother to acquire different developmental fates. In Caenorhabditis elegans, the Wnt/β-catenin Asymmetry (WβA) pathway regulates many embryonic and larval ACDs; here, a Wnt gradient induces an asymmetric distribution of Wnt signaling components within the dividing mother cell. One terminal nuclear effector of the WβA pathway is the transcriptional activator SYS-1/β-catenin. SYS-1 is sequentially negatively regulated during ACD; first by centrosomal regulation and subsequent proteasomal degradation and second by asymmetric activity of the β-catenin "destruction complex" in one of the two daughter cells, which decreases SYS-1 levels in the absence of WβA signaling. However, the extent to which mother cell SYS-1 influen

SUBMITTER: Michel MFV 

PROVIDER: S-EPMC11974967 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature