Trajectories of genetic risk across dimensions of alcohol use behaviors.

ABSTRACT:

Background

Alcohol use behaviors (AUBs) manifest in a variety of normative and problematic ways across the life course, all of which are heritable. Twin studies show that genetic influences on AUBs change across development, but this is usually not considered in research identifying and investigating the genes linked to AUBs.

Aims

Understanding the dynamics of how genes shape AUBs could point to critical periods in which interventions may be most effective and provide insight into the mechanisms behind AUB-related genes. In this project, we investigate how genetic associations with AUBs unfold across development using longitudinal modelling of polygenic scores (PGSs).

Design

Using results from genome-wide association studies (GWASs), we created PGSs to index individua

SUBMITTER: Savage JE 

PROVIDER: S-EPMC11974985 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature