Nanometer scale difference in myofilament lattice structure of muscle alters muscle function in a spatially explicit model.

ABSTRACT: Crossbridge binding, state transitions, and force in active muscle is dependent on the radial spacing between the myosin-containing thick filament and the actin-containing thin filament in the filament lattice. This radial spacing has been previously shown through spatially explicit modeling and experimental efforts to greatly affect quasi-static, isometric, force production in muscle. It has recently been suggested that this radial spacing might also be able to drive differences in mechanical function, or net work, under dynamic oscillations like those which occur in muscles in vivo. However, previous spatially explicit models either had no radial spacing dependence, meaning the radial spacing could not be investigated, or did include radial spacing dependence but could not reproduce in v

SUBMITTER: Tune TC 

PROVIDER: S-EPMC11975381 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature