Prognostic Value of Left Ventricular ¹⁸F-Florbetapir Uptake in Systemic Light-Chain Amyloidosis.

ABSTRACT:

Background

Positron emission tomography/computed tomography (PET/CT) with ¹⁸F-florbetapir, a novel amyloid-targeting radiotracer, can quantify left ventricular (LV) amyloid burden in systemic light-chain (AL) amyloidosis. However, its prognostic value is not known.

Objectives

The authors' aim was to evaluate the prognostic value of LV amyloid burden quantified by ¹⁸F-florbetapir PET/CT, and to identify mechanistic pathways mediating its association with outcomes.

Methods

A total of 81 participants with newly diagnosed AL amyloidosis underwent ¹⁸F-florbetapir PET/CT imaging. Amyloid burden was quantified using ¹⁸F-florbetapir LV uptake as percent injected dose. The Mayo stage for AL amyloidosis was determined using troponin T

SUBMITTER: Clerc OF 

PROVIDER: S-EPMC11975406 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature