Acute Sleep Loss Increases Circulating Morning Levels of Two MicroRNAs Implicated in Neurodegenerative Disease in Healthy Young Men.

ABSTRACT: Chronic sleep disruption and shift work elevate the risk of neurodegeneration and Alzheimer's disease (AD). While disrupted sleep affects canonical AD biomarkers, its impact on other mechanisms, such as circulating microRNAs (miRNAs), remains less understood. Therefore, we here examined the effects of overnight wakefulness on plasma levels of several miRNAs implicated in neurodegeneration and AD, as well as in sleep and circadian regulation-namely miR-127-3p, miR-132-3p, and miR-142-3p. Following a baseline period in each highly controlled in-lab session, in total 15 healthy normal-weight young men underwent two conditions on separate occasions, in randomised order: a night of normal sleep, and a night of sustained wakefulness. After overnight wakefulness, morning plasma levels of miR-127-

SUBMITTER: Zhang L 

PROVIDER: S-EPMC11975503 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature