Enhanced analysis of the genomic diversity of <i>Mycobacterium bovis</i> in Great Britain to aid control of bovine tuberculosis.

ABSTRACT: Bovine tuberculosis (bTB) is an endemic disease in Great Britain (GB) that affects mainly cattle but also other livestock and wild mammal species, leading to significant economic and social impact. Traditional genotyping of Mycobacterium bovis (M. bovis) isolates, which cause bTB, had been used routinely since the late 1990s as the main resource of genetic information in GB to describe their population and to understand their epidemiology. Since 2017, whole-genome sequencing (WGS) has been implemented on M. bovis isolates collected during routine surveillance. In this study, we analysed genome sequences from 3,052 M. bovis isolates from across GB to characterise their diversity and population structure in more detail. Our findings show that the M. bovis p

SUBMITTER: Sandhu P 

PROVIDER: S-EPMC11975571 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature