Normative Modeling Reveals Age-Atypical Cortical Thickness Differences Between Hepatic Steatosis and Fibrosis in Non-Alcoholic Fatty Liver Disease.

ABSTRACT:

Objectives

To investigate individual variations and outliers in cortical thickness among non-alcoholic fatty liver disease (NAFLD) patients, ranging from hepatic steatosis to fibrosis, using neuroanatomical normative modeling.

Materials and methods

A cross-sectional study with 2637 health check-up subjects was conducted. Among NAFLD patients, hepatic steatosis (n = 556) and fibrosis (n = 57) were determined by hepatic steatosis index and fibrosis-4 score, respectively. Cortical thickness in 148 different brain regions was assessed using T1-weighted MRI scans. A publicly available neuroanatomical normative model analyzed cortical thickness distributions with data from around 58,000 participants. The hierarchical Bayesian regression was used to estimate cortical thickness devi

SUBMITTER: Kim M 

PROVIDER: S-EPMC11975609 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature