Galacto-oligosaccharides alleviate experimental lactose intolerance associated with gut microbiota in mice.

ABSTRACT:

Introduction

Galacto-oligosaccharides (GOS) are beneficial for alleviating lactose intolerance (LI). GOS have the ability to modify the composition of the intestinal microbiota. The development of intestinal diseases could be influenced by the composition of the gut microbiota. Nevertheless, it remains unclear whether gut microbiota exerts an effect when GOS alleviate LI, whether alterations in composition of the intestinal microbiota influence inflammatory response and lactose digestion.

Methods

We first investigated the effects of GOS on mice with established lactose intolerance. Next, we demonstrated that prophylactic supplementation with GOS also conferred similar benefits.

Results

The results showed that GOS enhanced anti-inflammatory, antioxidant, and gut barrie

SUBMITTER: Li Q 

PROVIDER: S-EPMC11975899 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature