Emergence of invasive candidiasis with multiple <i>Candida</i> species exhibiting azole and echinocandin resistance.

ABSTRACT:

Background

Invasive candidiasis (IC) is an increasingly common, expensive, and potentially fatal infection. However, IC caused by multiple Candida species is rarely reported in China. Herein, we revealed a complex IC caused by multiple Candida species, comprising the rare C. norvegensis, C. albicans, C. glabrata, and C. tropicalis. The resistance mechanism of azole and echinocandin resistance were explored further.

Methods

The isolates were confirmed using internal transcribed spacer (ITS) sequencing. The resistance mechanisms were investigated using PCR-based sequencing, quantitative real-time reverse transcription PCR, and rhodamine 6G efflux quantification.

Results

Antifungal susceptibility testing showed this complex infec

SUBMITTER: Huang SJ 

PROVIDER: S-EPMC11975943 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature