Antiresorptive medication-related osteonecrosis of the jaw: Incidence and preventive measures utilization in cancer patients.

ABSTRACT:

Introduction

Antiresorptive drugs are commonly used to treat cancer and bone metastases. These drugs can impose the risk of osteonecrosis of the jaw (ONJ). ONJ is a serious complication that can lead to significant morbidity and mortality. This study aimed to investigate the incidence and preventive measures utilization of ONJ among cancer patients treated with antiresorptive agent.

Materials and methods

This retrospective cohort study investigated 210 adult patients with cancer on either zoledronic acid (ZA) or denosumab at a tertiary cancer center. The primary endpoint was to determine the incidence rate of Osteonecrosis of the Jaw. Secondary endpoints were to determine the utilization rate of antiresorptive agent related ONJ preventive measures and the exposure duration o

SUBMITTER: Alabdali SA 

PROVIDER: S-EPMC11976093 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature