A Randomized Controlled 'REAL-FITNESS' Trial to Evaluate Physical Activity in Patients With Newly Diagnosed Multiple Myeloma.

ABSTRACT:

Background

Multiple myeloma (MM) is the second most common haematological malignancy. The predominantly older patients often suffer from comorbidities that impair their quality of life (QoL). Physical activity (PA) can be beneficial for cancer patients, but less evidence exists in MM. This randomized controlled trial (RCT) compared an exercise group with World Health Organization (WHO)-compliant PA (150 min aerobic exercise and 2 resistance training-sessions/week) vs. activity as usual (control group).

Methods

Thirty-four newly diagnosed consecutive MM patients were randomized 1:1 to exercise vs. control groups. Guided training (2×/week) was performed for 3 months during bortezomib-cyclophosphamide-dexamethasone (VCd) induction. PA was monitored using smartwatches and diarie

SUBMITTER: Dreyling E 

PROVIDER: S-EPMC11976162 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature