Steady State Free Precession NMR without Fourier Transform: Redefining the Capabilities of ¹⁹F NMR as a Discovery Tool.

ABSTRACT: The 2024 Zurich perfluorinated compounds (PFCs) summit reiterated the urgent need for non-selective analytical approaches for PFC detection. ¹⁹F NMR holds great potential, however, sensitivity limitations lead to long analysis times and/or the possibility of not detecting low concentration species. Steady State Free Precession (SSFP) NMR collects the signal in a steady state regime, allowing 100's of acquisitions in the timespan of a single traditional NMR scan. Unfortunately, data truncation from SSFP leads to artifacts and spectral broadening with Fourier transform, hindering interpretation. When non-Fourier based time-domain analysis is used, namely, complete reduction to amplitude frequency tables (CRAFT), limitations of SSFP are eliminated while sensitivity gains are retain

SUBMITTER: Gauthier JR 

PROVIDER: S-EPMC11976210 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature