Radiation-induced sarcoma after radiotherapy for breast cancer: A retrospective case series.

ABSTRACT: Radiation-induced breast sarcoma (RIBS) is a rare yet serious complication of radiotherapy for breast cancer, with limited data from the Middle East. This case series examines four patients with RIBS at a tertiary healthcare center in Saudi Arabia, highlighting a notably short latency period and an uncommon histological pattern. The mean age at breast cancer diagnosis was 44.75 years, and RIBS developed at a mean age of 48.25 years after an average latency of 43 months. One patient with a TP53 mutation had the shortest latency (28 months), suggesting a possible genetic predisposition. Histopathological evaluation confirmed undifferentiated pleomorphic sarcoma in all cases, distinct from the more commonly reported angiosarcoma. Radiologic assessments, including mammography, ultrasound, PET-

SUBMITTER: Alshehri SSA 

PROVIDER: S-EPMC11976226 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature