Chromatin landscape in paired human visceral and subcutaneous adipose tissue and its impact on clinical variables in obesity.

ABSTRACT:

Background

Obesity is a global health challenge and adipose tissue exhibits distinct depot-specific characteristics impacting differentially on the risk of metabolic comorbidities.

Methods

Here, we integrate chromatin accessibility (ATAC-seq) and gene expression (RNA-seq) data from intra-individually paired human subcutaneous (SAT) and omental visceral adipose tissue (OVAT) samples to unveil depot-specific regulatory mechanisms.

Findings

We identified twice as many depot-specific differentially accessible regions (DARs) in OVAT compared to SAT. SAT-specific regions showed enrichment for adipose tissue enhancers involving genes controlling extracellular matrix organization and metabolic processes. In contrast, OVAT-specific regions showed enrichment in promoters linked

SUBMITTER: Saeed S 

PROVIDER: S-EPMC11976249 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature