Pleiotropic role of GAS6 in cardioprotection against ischemia-reperfusion injury.

ABSTRACT:

Introduction

Myocardial ischemia-reperfusion (IR) injury is a common medical issue contributing to the onset and progression of ischemic heart diseases (IHD). Growth arrest-specific gene 6 (GAS6), a vitamin K-dependent secretory protein, promotes cell proliferation and inhibits inflammation and apoptosis through binding with Tyro3, Axl, and Mertk (TAM) receptors.

Objectives

Our study aimed to examine the effect of GAS6 pathways activation as a potential new treatment in myocardial IR injury.

Methods

Gain- and loss-of-function experiments were utilized to determine the roles of GAS6 in the pathological processes of myocardial IR injury.

Results

Our results revealed down-regulated levels of GAS6, Axl, and SIRT1 in murine hearts subjected to IR injury, and cardiom

SUBMITTER: Lu C 

PROVIDER: S-EPMC11976411 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature