Crosstalk between endothelial cells and dermal papilla entails hair regeneration and angiogenesis during aging.

ABSTRACT:

Introduction

Tissues maintain their function through interaction with microenvironment. During aging, both hair follicles and blood vessels (BV) in skin undergo degenerative changes. However, it is elusive whether the changes are due to intrinsic aging changes in hair follicles or blood vessels respectively, or their interactions.

Objective

To explore how hair follicles and blood vessels interact to regulate angiogenesis and hair regeneration during aging.

Methods

Single-cell RNA-sequencing (scRNA-seq) analyses were used to identify the declined ability of dermal papilla (DP) and endothelial cells (ECs) during aging. CellChat and CellCall were performed to investigate interaction between DP and ECs. Single-cell metabolism (scMetabolism) analysis and iPATH were applied

SUBMITTER: Zhou S 

PROVIDER: S-EPMC11976415 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature