Comorbidity in Midlife and Cancer Outcomes.

ABSTRACT:

Importance

Comorbidities in midlife are common but how these conditions are associated with cancer outcomes is poorly understood.

Objective

To investigate the association between different comorbidities and risk of incident cancer and cancer mortality.

Design, setting, and participants

This cohort study is a secondary analysis of the prospective Prostate, Lung, Colorectal, and Ovarian (PLCO) screening trial conducted at 10 PLCO screening centers across the US. Participants included adults aged 55 to 74 years without a history of cancer enrolled between 1993 and 2001. Statistical analysis was performed from June 2023 to December 2024.

Exposures

Self-reported history of 12 comorbid conditions classified into 5 distinct classifications guided by World Health Organ

SUBMITTER: Lavery JA 

PROVIDER: S-EPMC11976491 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature