Time-restricted eating and autosomal dominant polycystic kidney disease: a pilot, randomized clinical trial.

ABSTRACT:

Background

Autosomal dominant polycystic kidney disease (ADPKD) is the most commonly inherited progressive kidney disease. Time-restricted eating (TRE) is a fasting regimen that restricts eating to a particular window (typically 8 hours/day), which could slow cyst growth based on preclinical models.

Methods

A 12-month, randomized, controlled, behavioral dietary intervention compared TRE with a control group given healthy eating advice without TRE (HE), without caloric restriction. Participants underwent baseline and 12-month measurements, including adherence (percentage of participants adhering to the 8-hour window; primary outcome), and MRI to determine height-adjusted total kidney volume (htTKV) and adiposity.

Results

Twenty-nine participants (23 females, mean stand

SUBMITTER: Steele C 

PROVIDER: S-EPMC11976525 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature