The efficacy and safety of RNA interference for the treatment of primary hyperoxaluria: a systematic review and meta-analysis.

ABSTRACT: Primary hyperoxaluria (PH) are rare inherited disorders of liver glyoxylate metabolism. The main symptoms are related to the precipitation of calcium oxalate crystals in the urinary tract with progressive renal damage. The severity of disease can result in kidney failure and systemic oxalosis. Until recently, RNA interference (RNAi) has been demonstrated as a therapeutic avenue for PH. We conducted a systematic review and meta-analysis to assessed the efficacy and safety of RNAi in the treatment of PH patients. The present systemic review systematically and comprehensively summarizes the pathophysiological mechanisms by which hyperoxalemia leads to kidney failure. Furthermore, we provide a detailed summary of the mechanisms of RNAi drug action in the pharmacological treatment of PH. The en

SUBMITTER: Yu H 

PROVIDER: S-EPMC11976527 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature