Primary FSGS is not associated with worse kidney outcome compared with other FSGS subtypes.

ABSTRACT:

Background

Studies that compare kidney outcomes across patients with different forms of focal segmental glomerulosclerosis (FSGS) are lacking.

Methods

This retrospective study compared annual estimated glomerular filtration rate (eGFR) slope and kidney failure rate (eGFR <15 mL/min/1.73 m² or initiation of kidney replacement therapy) across patients with biopsy-proven primary, maladaptive, genetic and undetermined FSGS. Patients were included from two Belgian tertiary referral hospitals, from 2010 until 2022. Associations between covariates and kidney failure were estimated using Cox and Fine and Gray models. eGFR slopes were estimated using linear mixed-effects models.

Results

Eighty-two patients were subdivided into primary (28.1%), maladaptive (40.2%), g

SUBMITTER: Deleersnijder D 

PROVIDER: S-EPMC11976529 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature