The Predictive Value of BUB1 in the Prognosis of Oral Squamous Cell Carcinoma.

ABSTRACT:

Background

Oral squamous cell carcinoma (OSCC) is the most common type of malignant tumour in the oral cavity, and it is known for its poor prognosis. Budding uninhibited by benzimidazoles 1 (BUB1) may be related to cancer prognosis; however, the specific relationship between BUB1 and OSCC prognosis remains largely unexplored.

Methods

The mRNA levels of BUB1 were analysed using data from the TCGA_OSCC and GSE23558 cohorts. OSCC samples from the TCGA_OSCC dataset were divided into low- and high-BUB1 expression groups based on the median BUB1 level. Furthermore, results of survival analysis, tumour mutation burden (TMB), gene set enrichment analysis (GSEA) pathways, and drug-sensitivity analysis were compared between the 2 groups.

Results

Based on the data from the TCGA

SUBMITTER: Li X 

PROVIDER: S-EPMC11976542 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature