Periodontitis and Hepatocellular Carcinoma: A Two-Sample Mendelian Randomisation Study.

ABSTRACT:

Introduction and aims

Observational studies have reported conflicting associations between periodontitis (PD) and hepatocellular carcinoma (HCC). To overcome these limitations, we performed a two-sample Mendelian randomization (MR) analysis to investigate the potential association between PD and HCC.

Methods

We used summary data from genome-wide association studies (GWASs) of European ancestry, integrating data from chronic/acute periodontitis (CP/AP) samples (n1 = 34,615; n2 = 277,036; n3 = 410,811) and HCC samples (n1 = 456,348; n2 = 475,638). The inverse variance-weighted (IVW) approach represents our primary analysis method, supplemented by MR-Egger regression, weighted median, weighted-mode, and simple-mode methods. Pleiotropy and heterogeneity tests were also performed

SUBMITTER: Sergeeva I 

PROVIDER: S-EPMC11976544 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature