Association Between Circulating Inflammatory Cytokines and Dentofacial Anomalies.

ABSTRACT:

Introduction and aims

Previous studies have shown that some inflammatory cytokines are associated with dentofacial anomalies (DA), but the causal relationship is unclear. Therefore, the present study aimed to elucidate the relationship between circulating inflammatory cytokines, and DA risk by Mendelian randomization analysis.

Methods

A two-way two-sample Mendelian randomization analysis was used in our study. Data on 91 inflammatory cytokines were sourced from genome-wide association studies encompassing 14,824 participants across 11 distinct cohorts and protein quantitative trait loci from deCODE (35,559 participants). Summary statistics for DA were acquired from the FinnGen consortium (9254 cases and 245,664 controls). The inverse variance weighting method was used as the

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC11976546 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature