Study on PTFE superhydrophobic coating modified by IC@dMSNs and its enhanced antibacterial effect.

ABSTRACT:

Introduction

Vascular catheter-related infections and thrombosis are common and may lead to serious complications after catheterization. Reducing the incidence of such infections has become a significant challenge.

Objectives

This study aims to develop a super hydrophobic nanocomposite drug-loaded vascular catheter that can effectively resist bacterial infections and blood coagulation.

Methods

In this study, a SiO₂ nanocoated PTFE (Polytetrafluoroethylene) catheter (PTFE-SiO₂) was prepared and further optimized to prepare a SiO₂ nanocoated PTFE catheter loaded with imipenem/cilastatin sodium (PTFE-IC@dMSNs). The catheters were characterized for performance, cell compatibility, anticoagulant performance, in vitro and in vivo antibacteri

SUBMITTER: Zhang W 

PROVIDER: S-EPMC11976563 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature