Association of intestinal anti-inflammatory drug target genes with psychiatric Disorders: A Mendelian randomization study.

ABSTRACT:

Introduction

Psychiatric disorders present a substantial global public health burden with limited drug options. The gut-brain axis connects inflammatory bowel diseases and psychiatric disorders, which often have comorbidities. While some evidence hints at anti-inflammatory drugs aiding in treating psychiatric conditions, the specific effects of intestinal anti-inflammatory drugs remain unclear.

Objectives

This study investigates the causal effect of intestinal anti-inflammatory drug targets on psychiatric disorders. We hypothesize that these drug targets may offer new insights into the treatment and prevention of such disorders. Additionally, we explore gut microbiota's mediating role between drug target genes and psychiatric disorders.

Methods

We performed two-sample

SUBMITTER: Zhao G 

PROVIDER: S-EPMC11976564 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature