Mendelian Randomization Reveals No Causal Association Between Periodontitis and Infective Endocarditis.

ABSTRACT:

Objectives

Clarifying the uncertain causal relationship between periodontitis and infective endocarditis using Mendelian randomization analysis, given their historically perceived association and clinical significance.

Methods

Genetic variation data for acute periodontitis, chronic periodontitis, aggressive periodontitis, and infective endocarditis were obtained from published GWAS in individuals of European ancestry. Instrumental variables significantly associated with periodontitis were selected and univariable Mendelian randomization was conducted to infer the causal association between periodontitis and infective endocarditis. Multivariable Mendelian randomization was also performed to adjust for potential confounders including smoking, drinking, diabetes, and education.

SUBMITTER: Liu RL 

PROVIDER: S-EPMC11976596 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature