Identification of Potential Biomarkers and Therapeutic Targets for Periodontitis.

ABSTRACT:

Background

Periodontitis is a chronic and multifactorial inflammatory disease. However, existing medications often lack sufficient therapeutic effects. The aim is to identify potential biomarkers and efficient therapeutic targets using Mendelian randomisation (MR) and single-cell analysis.

Methods

MR analysis was conducted based on the cis-expression quantitative trait loci (cis-eQTLs) extracted from the eQTLGen Consortium and genome-wide association study (GWAS) data of periodontitis sourced from the Gene Lifestyle Interactions in Dental Endpoints (GLIDE) consortium (17,353 cases, 28,210 controls). Subsequently, colocalisation analysis was employed to detect whether genes and periodontitis shared the same casual variant. Finally, enrichment analysis, protein-protein interac

SUBMITTER: Huoshen W 

PROVIDER: S-EPMC11976599 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature