Testing the Causal Association Between Metabolic Syndrome and Periodontitis: A Two-sample Mendelian Randomisation Study.

ABSTRACT:

Introduction and aims

Observational studies suggest an association between metabolic syndrome (MetS) and periodontitis. However, observational studies are susceptible to reverse causation and confounding factors, so the causality of this association is uncertain. Causal association between compounds of MetS and periodontitis has been well studied. Using Mendelian randomisation (MR), we aimed to comprehensively evaluate the bidirectional relationship between MetS as a whole and periodontitis and provide clinical insight.

Methods

We used genetic instruments from the most comprehensive genome-wide association studies of European descent for MetS (n = 291,107) as well as periodontitis from both the FinnGen consortium (n = 195,395) and GeneLifestyle Interactions in Dental Endpoin

SUBMITTER: Yan J 

PROVIDER: S-EPMC11976632 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature