Renal denervation achieves its antiarrhythmic effect through attenuating macrophage activation and neuroinflammation in stellate ganglia in chronic heart failure.

ABSTRACT:

Aims

Renal denervation (RDN) is widely investigated in multiple studies of sympathetically driven cardiovascular diseases. While the therapeutic potential of RDN for ventricular arrhythmia has been reported, the mechanisms responsible for its antiarrhythmic effect are poorly understood. Our recent study showed that macrophage expansion-induced neuroinflammation in the stellate ganglion (SG) was a critical factor for cardiac sympathetic overactivation and ventricular arrhythmogenesis in chronic heart failure (CHF). This study investigates if and how RDN decreases ventricular arrhythmias by attenuating neuroinflammation in cardiac sympathetic post-ganglionic (CSP) neurons in CHF.

Methods and results

Rat CHF was induced by surgical ligation of the left anterior descending (LAD)

SUBMITTER: Hu W 

PROVIDER: S-EPMC11976725 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature