Sympathetic-Mediated Intestinal Cell Death Contributes to Gut Barrier Impairment After Stroke.

ABSTRACT: Tissue injury induced by stroke is traditionally thought to be localised to the brain. However, there is an accumulating body of evidence to demonstrate that stroke promotes pathophysiological consequences in peripheral tissues including the gastrointestinal system. In this study, we investigated the mechanisms underlying gut permeability after stroke. We utilised the clinically relevant experimental model of stroke called permanent intraluminal middle cerebral artery occlusion (pMCAO) to examine the effect of cerebral ischaemia on the gut. We detected stroke-induced gut permeability at 5 h after pMCAO. At this timepoint, we observed significantly elevated intestinal epithelial cell death in post-stroke mice compared to their sham-operated counterparts. At 24 h after stroke onset when the

SUBMITTER: Prame Kumar K 

PROVIDER: S-EPMC11976816 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature