Iridium porphyrin-catalysed asymmetric carbene insertion into primary N-adjacent C-H bonds with TON over 1000000.

ABSTRACT: Selective functionalization of ubiquitous C-H bonds in organic molecules provides a straightforward and efficient approach to construct complex molecules with fewer synthetic steps and high atom economy, thus promoting more sustainable and economical chemical synthesis. A formidable challenge in the field is to increase the turnover numbers (TONs) for catalytic C-H functionalization reactions reported in the literature (generally <10,000) to reasonably high levels to reduce the cost of the reaction. Another challenge is the selective functionalization of less reactive primary C(sp³)-H bonds compared to other types of more reactive C-H bonds. We now demonstrate an efficient iridium porphyrin-catalysed asymmetric carbene insertion into primary N-adjacent C(sp³)-H bond o

SUBMITTER: Li ZR 

PROVIDER: S-EPMC11976952 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature