PET imaging of hepatocellular carcinoma with [¹²⁴I]IV-14.

ABSTRACT:

Background

Currently, positron emission tomography (PET) plays no clear role in clinical imaging and management of hepatocellular carcinoma (HCC). New radiotracers for new target(s) are needed for PET imaging of HCC. Uridine-cytidine kinase 2 (UCK2) is a rate-limiting enzyme of the pyrimidine salvage synthesis pathway to phosphorylate uridine and cytidine. Studies have demonstrated that UCK2 is overexpressed in many types of solid cancers including HCC and is associated with the poor prognosis and proliferation of HCC. This study reported PET imaging using a UCK2-specific radiotracer with a clinically relevant anima model of spontaneously occurring HCC in the woodchucks.

Methods

This study used 3'-(E)-(2-iodovinyl) uridine (IV-14), which is derived from a UCK2-selective anti

SUBMITTER: Cao W 

PROVIDER: S-EPMC11977070 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature