Stabilized carbon coating on microelectrodes for scalable and interoperable neurotransmitter sensing.

ABSTRACT: Real-time monitoring of neurotransmitters is essential in driving basic neuroscience understandings and creating treatments for various brain disorders. However, current neurotransmitter sensing devices are highly limited in their spatiotemporal resolution and ability to integrate with neuronal recording. Here, we introduce a unique carbon coating approach to achieve high-performance voltammetry electrodes with extraordinary scalability and interoperability. Surprisingly, we discovered that mild annealing drastically improves the electrochemical stability of graphene-based carbon coating, enabling the transformation of conventional neuroelectrodes into fast-scan-cyclic-voltammetry-stable carbon sensors. We successfully validated sub-second detection of nanomolar dopamine in vivo using carb

SUBMITTER: Qi Y 

PROVIDER: S-EPMC11977211 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature