Affective bias predicts changes in depression during deep brain stimulation therapy.

ABSTRACT:

Introduction

Deep brain stimulation (DBS) is a promising treatment for refractory depression, utilizing surgically implanted electrodes to stimulate specific anatomical targets within the brain. However, limitations of patient-reported and clinician-administered mood assessments pose obstacles in evaluating DBS treatment efficacy. In this study, we investigated whether an affective bias task, which leverages the inherent negative interpretation bias seen in individuals with depression, could serve as a reliable measure of mood changes during DBS therapy in patients with treatment-resistant depression.

Methods

Two cohorts of patients (n = 8, n = 2) undergoing DBS for treatment-resistant depression at different academic medical centers completed an affective bias

SUBMITTER: Cui B 

PROVIDER: S-EPMC11977254 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature