Identification of a <i>Coxiella burnetii</i> outer membrane porin required for intracellular replication.

ABSTRACT: Coxiella burnetii is a gram-negative, obligate intracellular pathogen that causes human Q fever. Within host cells, C. burnetii proliferates in a spacious, acidic, lysosome-derived Coxiella-containing vacuole (CCV) by a process that requires the Dot/Icm type IVB secretion system to deliver effectors that manipulate host cell functions. A previous transposon mutagenesis screen identified the gene cbu0937 as being important for intracellular replication of C. burnetii. Here, the function of Cbu0937 was investigated. The cbu0937::Tn mutant had no detectable defect replicating in the axenic acidified citrate cysteine medium 2. Additionally, intracellular replication of the cbu0937::Tn mutant was not restored by co-infection of host cells with an

SUBMITTER: Yang Z 

PROVIDER: S-EPMC11977307 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature