Sphingosine-mediated death of <i>Pseudomonas aeruginosa</i> involves degradation of cardiolipin by the maintenance of outer lipid asymmetry system.

ABSTRACT: Respiratory infections with multiresistant Pseudomonas aeruginosa are a major clinical problem, affecting mainly patients with pre-existing lung diseases such as cystic fibrosis (CF) or chronic obstructive pulmonary disease but also immunocompromised or elderly patients. We have previously shown that sphingosine, which is abundantly present on epithelial cells of the respiratory tract in healthy humans and wild-type mice, but almost undetectable on the surface of epithelial cells of the respiratory tract from CF patients and CF mice, efficiently kills many bacterial species in vitro and in vivo. Here, we show that sphingosine very rapidly induces marked changes in the membrane of P. aeruginosa with a rolling of the membrane followed by destruction of the bacteri

SUBMITTER: Grassme H 

PROVIDER: S-EPMC11977310 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature