Global changes in <i>Staphylococcus aureus</i> virulence and metabolism during colonization of healthy skin.

ABSTRACT: Staphylococcus aureus and its antibiotic-resistant derivative, methicillin-resistant S. aureus (MRSA), are the leading causative agents of skin and soft tissue infections globally. S. aureus transiently colonizes the skin of healthy adults, and this transient colonization likely precedes an active infection. In recent years, there have been efforts to elucidate specific factors that help MRSA transition to an active infection, but the specific genetic determinants required for this transition following skin colonization are largely unknown. To address this question, we developed a model of asymptomatic colonization of mouse skin by MRSA. From this model, we could determine the MRSA and mouse transcriptional profiles by RNA sequencing (RNAseq) at 5- and 24-hour post-col

SUBMITTER: Enroth TJ 

PROVIDER: S-EPMC11977313 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature