The hypervirulent Type-1/Type-17 phenotype of <i>Cryptococcus neoformans</i> clinical isolates is specific to A/J mice.

ABSTRACT: Cryptococcus neoformans is a fungal pathogen that causes cryptococcal meningitis in immunocompromised individuals. Both host- and pathogen-specific factors are known to affect patient outcome, and recent studies showed that strain-specific differences in C. neoformans clinical isolates can influence virulence in A/J mice. However, it is unclear how the immunologic and genetic background of inbred mouse strains affects disease outcome during C. neoformans infection. In this study, we show that a hypervirulent phenotype is dependent on the host immune response and mouse genetic background. A/J mice intranasally infected with the hypervirulent isolates, UgCl247, UgCl422, and UgCl236, have increased neutrophil and T-cell recruitment when compared with infection with the re

SUBMITTER: Ding M 

PROVIDER: S-EPMC11977316 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature