Identification of glyoxalase A in group B <i>Streptococcus</i> and its contribution to methylglyoxal tolerance and virulence.

ABSTRACT: Group B Streptococcus (GBS) is a Gram-positive pathobiont that commonly colonizes the gastrointestinal and lower female genital tracts but can cause sepsis and pneumonia in newborns and is a leading cause of neonatal meningitis. Despite the resulting disease severity, the pathogenesis of GBS is not completely understood, especially during the early phases of infection. To investigate GBS factors necessary for bloodstream survival, we performed a transposon (Tn) mutant screen in our bacteremia infection model using a GBS mariner transposon mutant library previously developed by our group. We identified significantly underrepresented mutations in 623 genes that contribute to survival in the blood, including those encoding known virulence factors such as capsule, the β-hemolysin

SUBMITTER: Akbari MS 

PROVIDER: S-EPMC11977320 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature