Epidemiology of Group B <i>Streptococcus</i>: Maternal Colonization and Infant Disease in Kampala, Uganda.

ABSTRACT:

Background

Child survival rates have improved globally, but neonatal mortality due to infections, such as group B Streptococcus (GBS), remains a significant concern. The global burden of GBS-related morbidity and mortality is substantial. However, data from low and middle-income countries are lacking. Vaccination during pregnancy could be a feasible strategy to address GBS-related disease burden.

Methods

We assessed maternal rectovaginal GBS colonization and neonatal disease rates in a prospective cohort of 6062 women-infant pairs. Surveillance for invasive infant disease occurred in parallel at 2 Kampala hospital sites. In a nested case-control study, we identified infants <90 days of age with invasive GBS disease (iGBS) (n = 24) and healthy infants born to mothers c

SUBMITTER: Kyohere M 

PROVIDER: S-EPMC11977330 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature