Amphetamine use disorder is associated with striatum hypoactivation during anticipation of loss and reward.

ABSTRACT:

Background

Dysregulated ventral striatum function has been proposed as one important process occurring in individuals with substance use disorder. This study investigates the role of altered reward and loss anticipation, which is an important component of impaired decision-making, impulsivity, and vulnerability to relapse in individuals with amphetamine use disorder (AMP).

Aims

To determine whether AMP is associated with blunted striatum, prefrontal cortex, and insula signals during win and loss anticipation.

Methods

Participants with and without AMP (AMP+ n = 46, AMP- n = 90) from the Tulsa 1000 study completed a monetary incentive delay (MID) task during functional magnetic resonance imaging.

Results

Group main effects indicated that: (1) AMP+ e

SUBMITTER: May AC 

PROVIDER: S-EPMC11977447 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature