Smoking, alcohol and risk of sarcopenia: a Mendelian randomisation study.

ABSTRACT:

Objective

Observational studies have found that cigarette smoking increased the prevalence and incidence of sarcopenia, whereas alcohol consumption appeared to decrease the risk. These findings, however, may be susceptible to either confounding bias or reverse causation. We conducted a Mendelian randomisation (MR) study to appraise the causal relation of cigarette smoking and alcohol consumption to the risk of sarcopenia.

Methods

Genetic instruments associated with cigarette smoking (cigarettes per day) and alcohol consumption (drinks per week) were retrieved from the publicly available genome-wide association data. Individual-level, electronic medical record-linked data on sarcopenia, grip strength and appendicular lean mass were obtained from the UK Biobank. We performed t

SUBMITTER: Sha T 

PROVIDER: S-EPMC11977482 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature