Association of Genomic Prostate Score at positive margin with recurrence after radical prostatectomy.

ABSTRACT:

Objectives

To evaluate the utility of the 17-gene Genomic Prostate Score® (GPS; MDxHealth, Irvine, CA, USA) performed on prostate cancer at the positive margin of the radical prostatectomy (RP) for its association with risk of subsequent biochemical recurrence (BCR).

Patients and methods

We designed a case-cohort for the outcome of BCR, selecting 223 from a cohort of 813 RP patients treated at Johns Hopkins from 2008 to 2017 with positive margins and available clinical data; of these, 213 had available tissue and clinical data. RNA was isolated from formalin-fixed paraffin-embedded tumour tissue adjacent to the positive surgical margin and the GPS was evaluable in 203 of these patients with a score ranging from 0 to 100, with higher scores indicating higher risk. All patient

SUBMITTER: Nourmohammadi Abadchi S 

PROVIDER: S-EPMC11977573 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature