Co-expression of diurnal and ultradian rhythms in the plasma metabolome of common voles (Microtus arvalis).

ABSTRACT: Metabolic rhythms include rapid, ultradian (hourly) dynamics, but it remains unclear what their relationship to circadian metabolic rhythms is, and what role meal timing plays in coordinating these ultradian rhythms in metabolism. Here, we characterized widespread ultradian rhythms under ad libitum feeding conditions in the plasma metabolome of the vole, the gold standard animal model for behavioral ultradian rhythms, naturally expressing ~2-h foraging rhythms throughout the day and night. These ultradian metabolite rhythms co-expressed with diurnal 24-h rhythms in the same metabolites and did not align with food intake patterns. Specifically, under light-dark entrained conditions we showed twice daily entrainment of phase and period of ultradian behavioral rhythms associated with phase ad

SUBMITTER: Psomas A 

PROVIDER: S-EPMC11977602 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature