Mendelian randomization analysis of the causal relationship between plasma proteins and childhood asthma.

ABSTRACT: Existing studies have suggested a significant association between plasma proteins and childhood asthma, but the specific causal relationship between them remains unclear. Therefore, we aimed to evaluate the causal relationship between plasma proteins and childhood asthma using Mendelian randomization (MR) methods. We conducted a 2-sample MR analysis and a reverse MR analysis. The GWAS summary statistics for plasma proteins were derived from a European population, covering a total of 4907 plasma proteins. The GWAS summary statistics for childhood asthma were obtained from the FinnGen database, including 3025 childhood asthma patients and 135,449 normal controls. Five MR methods, which include inverse-variance weighted, weighted median, MR-Egger, weighted mode, and simple mode, were utilized

SUBMITTER: Wang C 

PROVIDER: S-EPMC11977695 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature