Gastroesophageal reflux disease and osteoporosis: A bidirectional Mendelian randomization study.

ABSTRACT: In observational studies, associations between osteoporosis (OP) and gastroesophageal reflux disease (GERD) have been found. We conducted a 2-way, 2-sample Mendelian randomization (MR) analysis to determine whether these associations have a causal relationship. Data on GERD at the summary-level were sourced from extensive genome-wide association studies encompassing 129,080 cases and 473,524 control subjects. Bone mineral density (BMD) served as the phenotypic indicator for OP. BMD metrics were compiled from a cohort of 537,750 individuals, encompassing total body BMD (TB-BMD) and stratified TB-BMD across age groups, along with BMD measurements at 4 anatomical locations: lumbar spine, femoral neck, heel, and ultra-distal forearm. Multiple MR approaches, such as the inverse-variance weighte

SUBMITTER: Yang Q 

PROVIDER: S-EPMC11977714 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature