Analyzing the causal relationship between gut microbiotas, blood metabolites, and COVID-19 susceptibility: A Mendelian randomization study.

ABSTRACT: Gut microbiota and blood metabolites play crucial roles in the progression and outcomes of COVID-19, but the causal relationships and mechanisms remain unclear. Our aim is to use two-sample Mendelian randomization (MR) to explore the causal relationships between gut microbiota, COVID-19 susceptibility, and potential mediating blood metabolites. We utilized summary statistics from the largest genome-wide association studies (GWAS) to date on gut microbiota (n = 18,340), blood metabolites (n = 115,078), and COVID-19 susceptibility (cases n = 60,176 and controls n = 1310,725 from the COVID-19 Host Genetics Initiative meta-analysis). We conducted bidirectional MR analyses to explore the causal relationships between gut microbiota and COVID-19 susceptibility and performed two-step MR to identif

SUBMITTER: Yao XY 

PROVIDER: S-EPMC11977742 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature