Mendelian-based urolithiasis risk concerning fish consumption and fish oil supplement.

ABSTRACT: The link between fish consumption and urolithiasis risk has been observed in previous observational studies, yet a definitive causal relationship remains uncertain. We acquired data regarding fish consumption, fish oil supplementation, and urolithiasis from publicly available large-scale genome-wide association studies (GWAS). Urolithiasis data were sourced from the FinnGen consortium, comprising 5347 cases and 213,445 controls. Information on fish consumption and fish oil supplementation was extracted from the UK Biobank, encompassing 460,443 samples for oily fish consumption, 460,880 samples for non-oily fish consumption, and 461,384 samples for fish oil intake. We conducted 2-sample Mendelian randomization (MR) analyses employing random effects inverse variance weighting, weighted media

SUBMITTER: Zhu J 

PROVIDER: S-EPMC11977755 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature